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For the production of diagnostic and therapeutic antibodies, the only way to get good antibodies with all required properties is to have a large number of antibody candidates first. It is very common that a good antibody (pair) can only be discovered from 100-300 regular binders raised using different methods in different animals, thus having very diverse properties and sequences. https://www.creative-biolabs.com/Magic-Therapeutic-Antibody-Discovery-Service.htm