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The antigen binding regions of an antibody (variable heavy and light chain genes) are able to be isolated using phage display. Apart from altering the Fc portion of an antibody, the variable region of an immunoglobulin enables to be reformatted into a number of different fragments, including Fab, F(ab)’2, scFv, VHH, and minibodies. Due to their smaller antibody formats, increased tumour/tissue penetration, as well as relative ease of expression in non-mammalian systems, they play an increasingly important role in drug discovery and clinical research. As an undisputed lead in the antibody engineering area, Creative Biolabs provides a full range of structure-based antibody reformatting services by using in silico technology. antibody reformatting
https://www.creative-biolabs.com/preciab/structure-based-antibody-reformatting.htm